Author Archives: Dan Frost

Viral Phenotype and Immune Response in Primary Human Immunodeficiency Virus Type 1 Infection. Part 4

The number of clinical symptoms correlated significantly with both the duration and peak values ofCD8+ lymphocytosis (P < .05 for both comparisons in the Spearman nonparametric rank correlation test). CD8+ T cell numbers were moderately elevated in 5 of II cohort participants and within a normal range in the 6 others (data not shown). Although […]

March 18, 2011 – 9:58 pm | By Dan Frost | Posted in Infections | Comments (0)

Viral Phenotype and Immune Response in Primary Human Immunodeficiency Virus Type 1 Infection. Part 3

Virologic analysis. In patients 1-7 seroconversion occurred 11-27 days after the onset ofsymptoms. In patient 8, despite early treatment with zidovudine, seroconversion occurred 41 days after exposure to HIV-I-infected blood. Transient HIV-l antigenemia before seroconversion was detected in seven of eight patients. In patients 1-5 only NSI isolates were recovered. In patients 6 and 8 […]

March 15, 2011 – 9:35 pm | By Dan Frost | Posted in Infections | Comments (0)

Viral Phenotype and Immune Response in Primary Human Immunodeficiency Virus Type 1 Infection. Part 2

The source of infection was unknown for 16 subjects. The virus donor could be identified for the accidentally infected subject 8, for subject 2, a monogamous heterosexual individual with a confirmed seropositive Zairean partner as single-risk factor, and for 1 of the 11 cohort participants, subject 17, a monogamous homosexual man. For subject 17, the […]

March 11, 2011 – 6:04 pm | By Dan Frost | Posted in Infections | Comments (0)

Viral Phenotype and Immune Response in Primary Human Immunodeficiency Virus Type 1 Infection

Nineteen individuals were studied for virologic and immunologic events during primary human immunodeficiency virus type 1 (HIV-l) infection. In 16 individuals only non-syncytium-inducing (NSI) isolates were detected; syncytium-inducing (SI) isolates were obtained from 3. Studies of transmitter-recipient pairs indicated that both NSI variants and SI variants were transmitted and that SI variants may be suppressed […]

March 10, 2011 – 9:47 pm | By Dan Frost | Posted in Infections | Comments (0)

Chronic Disease Association

When S. aureus and group A streptococci are thought of, typically boils and pharyngitis, respectively, come to mind rather than the severe infectious diseases that these organisms can cause. Thus, the lack of great attention to these organisms may have allowed them, unchecked, to cause a myriad of chronic diseases that are recognized but whose […]

March 9, 2011 – 6:42 pm | By Dan Frost | Posted in Diseases | Comments (0)

Acute Disease Association. Part 3

Thus, one or more streptococcal superantigens may contribute significantly to TSLS. The pathogenesis of other severe invasive streptococcal diseases remains obscure. To date, few studies have evaluated transmission of the TSLS organism, rates of carriage and infection, and serosusceptibility to SPEs. Such studies are greatly needed. Recently, we received 23 strains of group B streptococci […]

March 5, 2011 – 10:51 am | By Dan Frost | Posted in Diseases | Comments (0)

Acute Disease Association. Part 2

In children the case-fatality rate for influenza TSS appears to be — 90%, with a lower rate in adults. It is likely that infection with other viruses, such as parainfluenza virus, could result in similar TSS. Recalcitrant erythematous desquamating syndrome represents an unrelenting TSS that occurs in AIDS patients. This illness may continue for > […]

March 3, 2011 – 5:52 pm | By Dan Frost | Posted in Diseases | Comments (0)

Acute Disease Association

In the early 1980s, TSS was recognized as an illness primarily in women at or within 2 days of their menstrual period and particularly in women using higher-absorbency tampons. However, even at that time cases were being reported in women who were not menstruating and in children and men. With the removal ofthe highest- absorbency […]

March 2, 2011 – 1:39 pm | By Dan Frost | Posted in Diseases | Comments (0)

Role of Superantigens in Human Disease

Superantigens include bacterial products (mainly ofstreptococci and staphylococci) that stimulate T cells to proliferate nonspecifically through interaction with class II major histocompatibility complex products on antigen-presenting cells and then with variable regions on the fJ chain of the T cell receptor complex. They include pyrogenic toxins (streptococcal scarlet fever toxins of serotypes A, B, and […]

February 26, 2011 – 8:25 pm | By Dan Frost | Posted in Diseases | Comments (0)

HIV Infection and Aging. Results

Results. Both groups were comparable in regard to age (mean, 41 years for HIV-negative subjects and 39 years for HIV-positive subjects), sex (male sex, 14 [56%] of 25 HIVnegative subjects and 20 [77%] of 26 HIV-positive subjects), and education level (mean, 15 years for HIV-negative subjects and 16 years for HIV-positive subjects). HIV-positive subjects had […]

February 22, 2011 – 3:07 pm | By Dan Frost | Posted in Infections | Comments (0)